Effects of transcutaneous electrical acupoint stimulation on ovarian reserve of patients with diminished ovarian reserve in in vitro fertilization and embryo transfer cycles.

Zheng Y et al, J Obstet Gynaecol Res. 2015 Dec;41(12):1905-11

The Journal of Obstetric and Gynecological Research

In this controlled non randomised trial, 240 women either over the age of 35 or with poor ovarian reserve, who were undergoing IVF treatment for tubal blockage, were divided into a group that received electrostimulation to acupuncture points or into one of three control groups. Women who received hormonal treatment or had TEAS applied to acupuncture points had reduced FSH levels and higher antral follicle counts. The study showed that the 56 women who received the electrostimulation (TEAS) to acupuncture points had a significantly higher clinical pregnancy rate than the other groups. It is often thought that not much can be done to improve the chances of IVF patients with low ovarian reserve hence more high level trials are necessary to test this result.

 

Abstract

AIM:

The aim of this study was to investigate the effect of transcutaneous electrical acupoint stimulation (TEAS) on ovarian reserve in patients with diminished ovarian reserve undergoing in vitro fertilization and embryo transfer.

MATERIAL AND METHODS:

A total of 240 patients were randomly divided into the Han’s acupoint nerve stimulator TEAS treatment (TES), comforting false Han’s placebo (FHP), artificial endometrial cycle treatment (AEC), and control (CON) groups.

RESULTS:

Fifty-six patients in TES, 56 in FHP, 54 in AEC, and 60 in CON fulfilled the study, respectively. Antral follicle count and anti-Müllerian hormone levels were increased, whereas the estradiol level, follicle-stimulating hormone level, and follicle-stimulating hormone/luteinizing hormone ratio were significantly decreased after treatment in the TES and AEC groups. After treatment, the number of oocytes retrieved and average number of embryos transferred were higher in the TES and AEC than in the CON and FHP groups. Clinical pregnancy rate in the TES group was markedly higher than values obtained for the other three groups.

CONCLUSION:

TEAS and AEC treatments could improve basal endocrine levels in patients, and increase the number of oocytes retrieved and high-quality embryos. TEAS treatment could improve the clinical pregnancy rate in patients with decreased ovarian reserve during in vitro fertilization and embryo transfer cycles.

© 2015 Japan Society of Obstetrics and Gynecology.

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Low ov researve TEAS Zheng_et_al-2015-Journal_of_Obstetrics_and_Gynaecology_Research