Effects of traditional Korean medicine on anti-Mullerian hormone inpatients with diminished ovarian reserve: A retrospective study

Acupuncture-Pregnancy-307Junyoung Jo et al, Comp  Ther  Med  24 (2016) 118–122

Complementary Therapies in Medicine, Elsevier

This Pilot study examined the effect of taking traditional herbal formulas in 22 women who had very low ovarian reserve (measured as AMH <1.1ng/ml). They found that 2 months of taking the herbal formulas increased the AMH significantly (double)  in women below 38 years of age, but not over this age. This study now needs to be repeated with a larger number of women to confirm this result.


Objective: The purpose of the present study is to retrospectively evaluate the effect of traditional Korean medicine (TKM) on ovarian reserve by measuring serum anti-Müllerian hormone (AMH) levels in patients with diminished ovarian reserve (DOR).

Study design: We performed a retrospective chart review of patients with DOR who had received TKMfor at least 2 months and had undergone serum AMH tests before and after TKM treatment. A total of 22 patients with DOR were included in the study.

Results: There were no significant differences in AMH levels before and after TKM in all patients (n = 22,p = 0.237). However, when the study population was divided into two age groups (<38 (n = 12) and ≥38years (n = 10)) to determine whether there was a age-related difference in the effect of TKM with DOR, a significant increase in AMH levels before and after TKM was observed in the age <38 (p < 0.05).

Conclusions: TKM may provide an effective option for patients aged <38 years with DOR, but it should be interpreted cautiously as more rigorous research is needed. Further studies in a larger population are needed to confirm these results and to evaluate the effects of improved ovarian reserve on fertility outcomes following TKM in patients with DOR.